Dr. Incavo and fellow researchers recently had published, Drug Reaction with Eosinophilia and systemic Symptoms Syndrome after Total Knee Arthroplasty Infection and Placement of Antibiotic Spacer, in Arthroplasty Today. The research presents a rare case of a drug reaction complication after placement of an antibiotic-impregnated cement spacer. Antibiotic spacers placed during the first stage have been associated with a number of potential complications, including breakage, dislocation and allergic reactions.